Fig. 4

128 genes were differentially expressed in the MP mice compared to NP mice. (A,B) multi-dimensional (MDS) and scree plot showing 42% of the variance between MP (n = 8) and NP (n = 8) mice were due to dimension 1 and 2. (C) Heat map showing log CPM values of the top 100 differentially expressed genes (DEGS) ranked through hierarchical cluster profiling. Only 1 of the NP mice grouped into MP group. (D) Volcano plot analysis of DEGs showing 64 upregulated (red) and 64 down regulated genes (blue) in MP mice with P < 0.05, and false discovery rate (FDR) < 0.05, at logFC. (E) Significantly enriched gene ontology (GO) terms associated with biological processes (BP), cellular components (CC), and molecular function (MF) analysed through ShinyGO 0.8 ranked by FDR and fold change. (F) Chord Plot showing of CC GO terms and associated genes and their fold change. Graph generated through SR Plot.