Fig. 5
Cardiomyopathy related pathways were enriched by DE genes associated with ECM, cardiac contraction and membrane transport in MP mice. (A) Top 10 cellular signalling pathway analysis through Bio-Planet, 2019 for up regulated (red) and down regulated (blue) genes, P < 0.05, less stringent FDR of < 0.2. Applying stringent FDR of < 0.05 only produced top 2 pathways. (B,C) Sankey plot of genes involved in each of the top 10 upregulated and downregulated enriched Bio-Planet pathways within the 64 upregulated and 64 downregulated genes, respectively. (D) 5 of the top 10 disease perturbations in GEO UP cardiomyopathy related (red nodes). (E) Cluster map of top 40 genes associated with the top 10 disease perturbations, ranked by P value, FDR < 0.05. Enrichr was used for these enrichment analysis. Data can be found on https://maayanlab.cloud/Enrichr/enrich?dataset=cebccb1381901ed9014bc6aea9eabb9f.
