Table 3 Secondary outcomes.

From: Remimazolam and propofol combination in ischemic cerebrovascular disease endovascular treatment: a randomized study

 

P(n = 34)

R1(n = 31)

R2(n = 30)

χ²/F

P

Postoperative delirium(n, %)

    

POD 1

7(20.6)

4(12.9)

2(6.7)

0.649

1.000

POD 3

2(5.9)

1(3.2)

1(3.3)

POD 7

0

0

0

CAM-CR(mean ± SD)

    

PREOP

12.00 ± 1.13

11.73 ± 0.83

12.31 ± 1.14

2.274

0.1091

POD 1

14.88 ± 4.68##

12.61 ± 1.65*#

14.40 ± 2.82#

6.786

0.0024

POD 3

14.12 ± 4.54#

12.38 ± 1.56

13.13 ± 1.83

2.655

0.0763

POD 7

13.65 ± 3.37#

12.10 ± 1.68*

12.63 ± 1.47

3.561

0.0319

PND(n, %)

     

POD 1

5(14.7)

1(3.2)

1(3.3)

7.591

0.7921

POD 3

3(8.8)

0(/)

1(3.3)

  

POD 7

1(2.9)

0(/)

1(3.3)

  

POD 30

1(2.9)

0(/)

1(3.3)

  

POD 90

1(2.9)

1(3.2)

0(/)

  

POD 180

1(2.9)

1(3.2)

0(/)

  

MMSE(mean ± SD)

     

PREOP

25.12 ± 3.84

26.90 ± 2.51

25.45 ± 3.26

2.540

0.0850

POD 1

24.59 ± 4.70

26.29 ± 3.14

24.83 ± 3.24##

1.854

0.1624

POD 3

25.47 ± 4.21

27.03 ± 2.69

25.47 ± 4.72

1.456

0.2378

POD 7

26.56 ± 3.49#

27.48 ± 2.66

26.83 ± 3.10#

0.745

0.4777

POD 30

26.97 ± 3.10####

27.58 ± 2.61

27.03 ± 3.07#

0.415

0.6623

POD 90

26.91 ± 3.01####

27.68 ± 2.64

26.91 ± 3.01#

0.800

0.4521

POD 180

26.88 ± 2.79##

27.87 ± 2.14

26.88 ± 2.79

1.649

0.1984

BI index

     

PREOP

100.0(88.75, 100.0)

95.00(70.00, 100.0)

100(91.25, 100.0)

2.499

0.2866

POD 3

100.0(88.75, 100.0)

100.0(80.00, 100.0)

100.0(90.0, 100.0)

0.980

0.6126

POD 30

100.0(100.0, 100.0)##

100.0(100.0, 100.0) ##

100.0(100.0, 100.0)#

0.322

0.8515

POD 90

100.0(100.0, 100.0) ##

100.0(100.0, 100.0) ##

100.0(100.0, 100.0) #

1.048

0.5921

POD 180

100.0(100.0, 100.0) ##

100.0(100.0, 100.0) ##

100.0(100.0, 100.0) #

1.996

0.3686

  1. Note: Data are presented as the mean ± SD, number of patients (percentage), or median (inter-quartile range). *p < 0.05: significant compared to the P group; p < 0.05: significant compared to the R1 group; #p < 0.05, ##p < 0.01, and ####p < 0.0001: significant as compared to PREOP.
  2. Abbreviations: PND, perioperative neurocognitive disorder; MMSE, Mini-mental State Examination; BI index, Barthel Index; PREOP, pre-operation; POD, post-operation day.