Table 2 Association between the occurrence of variants potentially implicated in severe COVID-19 and clinical/laboratory parameters.

From: Rare genetic variants and severe COVID-19 in previously healthy admixed Latin American adults

 

Without candidate variants (n = 72)

With candidate variants (n = 89)

p

OR (95% CI)

Group 1 (deaths)

11 (15.2%)

22 (24.7%)

0.140

0.55 (0.25–1.23)

Group 2 (ICU admissions)

61 (84.7%)

67 (75.2%)

  

Days from symptom onset to admission- Median (IQR)

10 (7–12)

9.5 (8–12)

0.656

-

Days in hospital- Median (IQR)

15 (9–20)

13 (10–36)

0.603

-

Clinical conditions during ICU hospitalization

    

Fever ≥ 38 ºC

13 (18.0%)

21 (23.5%)

0.599

0.80 (0.34–1.89)

Elevated RR (> 20)

37 (51.3%)

51 (57.3%)

0.928

1.09 (0.17–6.84)

Elevated HR (> 100)

21 (29.1%)

37 (41.5%)

0.150

0.54 (0.23–1.26)

Oxygen + low saturation (< 95%)

46 (63.8%)

60 (67.4%)

0.264

0.38 (0.07–2.18)

Laboratory results

Median (IQR)

  

Leukocyte (cells/mm³)

8,990 (5,675 − 12,145)

9,230 (6,170 − 12,100)

0.877

-

Neutrophil (cells/mm³)

8,001 (5,993 − 10,146)

8,307 (5,910 − 10,727)

0.868

-

Lymphocyte (cells/mm³)

922 (613-1,129)

854 (558-1,192)

0.764

-

Platelets (cells/mm3)

191,500 (119,750 − 275,000)

216,000 (160,000–287,500)

0.300

-

Bilirubin total (mg/dL)

0.53 (0.40–1.08)

0.50 (0.34–0.90)

0.400

-

Creatinine (mg/dL)

0.70 (0.50–0.88)

0.69 (0.17–0.88)

0.436

-

CRP (mg/L)

15.2 (9.4–27.6)

25.9 (7.25–93.50)

0.334

-

Complications during hospitalization

    

Vasopressor medication

16 (22.2%)

29 (26.9%)

0.290

1.55 (0.69–3.52)

Dialysis/hemodialysis

6 (8.3%)

6 (6.7%)

0.531

0.68 (0.20–2.29)

Sepsis

2 (2.7%)

6 (6.7%)

0.330

2.23 (0.42–11.70)

Shock

4 (5.5%)

7 (7.8%)

0.666

1.32 (0.36–4.82)

Renal insufficiency

3 (4.1%)

10 (11.2%)

0.144

2.69 (0.69–10.45)

Acute respiratory distress syndrome

17 (23.6%)

36 (40.4%)

0.027

2.59 (1.11–6.05)

Oxygen support

67 (93.0%)

84 (94.3%)

0.728

0.79 (0.22–2.87)

Ventilatory support

48 (66.6%)

67 (76.1%)

0.185

0.46 (−0.22- 1.16)

Orotracheal intubation

29 (40.2%)

44 (49.4%)

0.197

1.70 (0.75–3.80)

  1. Group 1 (deaths): patients who were admitted to the ICU but did not survive. Group 2 (ICU admissions): patients who remained in the ICU without progressing to death. P < 0.05 was considered statistically significant. Abbreviations – CRP: C-reactive protein; HR: heart rate; ICU: intensive care unit; IQR: interquartile range (first to third quartiles); RR: respiratory rate; OR (95% CI): Odds Ratio (95% Confidence Interval).
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