Table 6 Multivariate Cox regression: factors associated with hospital and ICU length of stay.

From: Tocilizumab as a targeted immunomodulatory therapy in the management of severe respiratory illnesses: a multicenter cohort study of COVID-19 patients

Variables

Dependent variable = hospital LOS

Dependent variable = ICU LOS

Wald

SE

p-value

OR (95% CI)

Wald

SE

pvalue

OR (95% CI)

Age

1.898

0.005

0.168

0.994 (0.985–1.003)

3.386

0.004

0.066

0.992 (0.983–1.001)

Gender

1.177

0.151

0.278

1.178 (0.876–1.585)

0.232

0.150

0.630

1.075 (0.801–1.444)

BMI

1.216

0.011

0.270

0.988 (0.967–1.010)

1.655

0.011

0.198

0.986 (0.965–1.008)

Corticosteroids during ICU stay

0.889

0.153

0.346

1.156 (0.856–1.561)

0.591

0.157

0.442

0.886 (0.651–1.206)

Tocilizumab

4.920

0.148

0.027**

0.720 (0.539–0.962)

0.774

0.153

0.379

0.874 (0.648–1.179)

Mean BP (mmHg)

0.671

0.004

0.413

1.003 (0.996–1.011)

0.108

0.004

0.742

1.001 (0.994–1.009)

Heart rate (bpm)

0.510

0.004

0.475

1.003 (0.995–1.010)

0.613

0.004

0.434

1.003 (0.995–1.011)

Respiratory rate

0.641

0.011

0.423

0.991 (0.971–1.013)

0.000

0.011

0.995

1.000 (0.979–1.021)

Oxygen saturation (%)

0.001

0.008

0.971

1.000 (0.985–1.016)

2.125

0.008

0.145

0.988 (0.973–1.004)

Glasgow Coma Score

0.632

0.029

0.427

0.977 (0.924–1.034)

0.469

0.031

0.493

0.979 (0.922–1.040)

Current smoker

5.999

0.143

0.014**

0.705 (0.533–0.933)

8.125

0.143

0.004**

0.665 (0.503–0.880)

Diabetes mellitus

0.085

0.296

0.771

1.090 (0.610–1.947)

0.542

0.303

0.461

1.250 (0.690–2.266)

Hypertension

1.930

0.155

0.165

1.240 (0.916–1.678)

1.988

0.157

0.159

1.247 (0.918–1.695)

Ischemic heart disease

1.263

0.161

0.261

1.198 (0.874–1.642)

1.090

0.161

0.297

1.184 (0.863–1.624)

Heart failure (EF < 50%)

2.432

0.241

0.119

0.687 (0.428–1.101)

1.547

0.245

0.214

0.738 (0.457–1.191)

Chronic lung disease

0.054

0.417

0.817

1.101 (0.486–2.494)

0.152

0.438

0.697

0.843 (0.357–1.990)

COPD

3.053

0.417

0.081

0.482 (0.213–1.093)

1.909

0.428

0.167

0.554 (0.239–1.281)

Bronchial asthma

1.031

0.541

0.310

1.733 (0.600–5.008)

0.157

0.565

0.692

1.251 (0.413–3.784)

Chronic liver disease

2.209

0.235

0.137

1.417 (0.895–2.245)

1.404

0.230

0.236

1.313 (0.837–2.058)

Hemoglobinopathy

0.062

0.540

0.803

1.144 (0.397–3.297)

0.352

0.525

0.553

0.732 (0.262–2.051)

CKD (GFR < 60 ml/min)

3.189

0.606

0.074

0.339 (0.103–1.111)

4.102

0.614

0.043**

0.288 (0.087–0.961)

Dialysis

2.485

0.383

0.115

1.828 (0.863–3.872)

0.297

0.397

0.586

1.242 (0.570–2.706)

Transplant (SOT/BMT)

0.901

0.373

0.343

0.702 (0.337–1.459)

0.023

0.388

0.879

0.943 (0.441–2.017)

Immunocompromised status

0.232

0.620

0.630

0.742 (0.220–2.501)

1.404

0.649

0.236

0.464 (0.130–1.653)

Chronic hematologic disease

0.553

0.483

0.457

0.698 (0.271–1.800)

0.568

0.428

0.451

1.381 (0.597–3.194)

HIV/AIDS

0.027

0.735

0.869

0.886 (0.210–3.740)

1.504

0.731

0.220

0.408 (0.097–1.710)

Recent surgery (within 30 days)

0.891

0.482

0.345

1.576 (0.613–4.052)

0.120

0.449

0.729

1.168 (0.485–2.816)

  1. **Significant, if p-value < 0.05.