Fig. 5 | Scientific Reports

Fig. 5

From: Population-based spectral characteristics of normal interictal scalp EEG inform diagnosis and treatment planning in focal epilepsy

Fig. 5

Differentiation of focal epilepsy and epileptogenic. (A-B) PSD and PC loadings of focal epilepsy patients (FOCAL-EPI) are compared to those of non-epileptic controls (CTL) across the four physiologic population factors. Loading values along y-axes are in arbitrary units. * indicates a significant difference with p < 0.05 and **** indicates a significant difference with p < 1e-4 in the Mann-Whitney-Wilcoxon test. (C) PSD and PC loadings are used as features to classify focal epilepsy vs. non-epileptic controls within a binary classification framework. (D-E) The same classification is broken down by temporal (TLE) and frontal (FLE) sub-types of focal epilepsy. (F) Differential diagnosis of the epileptogenic lobe, i.e., TLE vs. FLE, within the focal epilepsy cohort. Note that all classifications used only the four putative physiologic factors (1, 3, 4, and 5) and were conducted with three sets of features/loadings - only those of PSD factors (“PSD only”), only those of PC factors (“PC only”), or both concatenated (“PSD + PC”).

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