Fig. 4 | Scientific Reports

Fig. 4

From: The downregulation of ubiquitin-specific peptidase 2 indicates a poor prognosis and promotes the progression of gastric cancer through focal adhesion and ECM pathway signaling

Fig. 4

USP2 overexpression inhibits focal adhesion and the ECM pathway in GC cells. (A) Volcano plot of RNA-seq data from the NC and OE groups of HGC27 cells. OE group: overexpression of USP2; NC group: control group transfected with empty plasmid. The results of the GO-BP (B) and KEGG (C) functional enrichment analyses of the downregulated genes. (D) GSEA enrichment plot of the focal adhesion and ECM receptor interaction pathways. (E) Heatmap of DEGs in the ECM receptor interaction pathway. (F) Protein levels of focal adhesion pathway proteins in HGC27 and MGC803 cells. (G) mRNA levels of DEGs in the ECM receptor interaction pathway in HGC27 and MGC803 cells.

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