Fig. 2 | Scientific Reports

Fig. 2

From: Periplocin induces necroptosis in papillary thyroid carcinoma through DR4 mediated RIPK3 and MLKL signaling

Fig. 2

Periplocin induces necrotic-like changes in papillary thyroid carcinoma cells. (A and B) Hoechst 33,342/PI staining was used to detect morphological changes in TPC-1 and BCPAP cells treated with 0 or 125 nM periplocin, 125 nM periplocin + Nec-1 (20 µM), or 125 nM periplocin + ZVAD-FMK (50 µM) for 24 h. P < 0.05 was considered significant; ***P < 0.001 vs. control; ###P < 0.001 vs. 125 nM + Nec-1. Hoechst 33,342, Bisbenzimide H 33,342; Nec-1: necrostatin-1; PI: Propidium Iodide; ZVAD-FMK: Z-Val-Ala-Asp(OMe)-fluoromethylketone.

Back to article page