Table 2 Inhibitory activity of natural flavonoids and the brominated flavonoids toward BSA-glycation mediated methylglyoxal (MG).
From: Synthesis of promising brominated flavonoids as antidiabetic and anti-glycation agents
Compound | % Inhibition at 500 µM* | IC50 (µM)* |
|---|---|---|
Flavones | ||
Chrysin (F1) | 53.96 ± 2.71 | n.d |
6,8-Dibromochrysin (F1a) | 97.30 ± 0.19 | 50.90 ± 0.98 |
Apigenin (F2) | 73.66 ± 0.57 | n.d |
6,8-Dibromoapigenin (F2a) | 97.81 ± 2.08 | 57.01 ± 5.37 |
Luteolin (F3) | 96.32 ± 1.36 | 85.63 ± 4.97 |
6,8-Dibromoluteolin (F3a) | 95.37 ± 1.42 | 79.48 ± 1.10 |
Baicalein (F4) | 75.66 ± 1.96 | n.d |
8-Bromobaicalein (F4a) | 36.68 ± 1.35 | n.d |
Flavonols | ||
Kaempferol (F5) | 76.47 ± 1.05 | n.d |
6,8-Dibromokaempferol (F5a) | 72.24 ± 1.26 | n.d |
Morin (F6) | 94.69 ± 0.41 | 132.45 ± 2.47 |
6,8-Dibromomorin (F6a) | 92.81 ± 0.92 | 61.22 ± 5.98 |
Quercetin (F7) | 100,00 ± 0.00 | 68.47 ± 0.74 |
6,8-Dibromoquercetin (F7a) | 60.54 ± 2.14 | n.d |
Flavanones | ||
Pinocembrin (F8) | 47.60 ± 3.64 | n.d |
6,8-Dibromopinocembrin (F8a) | 46.31 ± 2.23 | n.d |
Pinostrobin (F9) | 11.90 ± 3.63 | n.d |
6,8-Dibromopinostrobin (F9a) | 37.21 ± 7.62 | n.d |
Alpinetin (F10) | 45.65 ± 2.69 | n.d |
6,8-Dibromoalpinetin (F10a) | 56.89 ± 4.28 | n.d |
Naringenin (F11) | 83.98 ± 3.08 | n.d |
6,8-Dibromonaringenin (F11a) | 51.62 ± 2.03 | 64.51 ± 6.87 |
Hesperetin (F12) | 51.62 ± 5.42 | n.d |
6,8-Dibromohesperetin (F12a) | 63.27 ± 2.80 | |
Aminoguanidine hydrochloride | 79.50 ± 1.49 | 240.05 ± 5.02 |
