Fig. 11
From: TFF3 initiates gastric intestinal metaplasia by activating JAK2 and STAT3 under high salt conditions
TFF3 regulates the JAK2/STAT3 pathway via IL-6. (A) IL-6 expression levels in GES-1 cells treated with NaCl and TFF3, determined by ELISA; (B) Levels of JAK2, p-JAK2, STAT3, p-STAT3, and CDX2 in GES-1 cells treated with 100 ng/mL and 200 ng/mL of IL-6, analyzed by Western blot; (C) Quantification of western blot results, normalized to GAPDH; (D) Schematic of the TFF3-JAK2/STAT3-CDX2 signaling pathway.
