Fig. 9

Consensus Clustering Analysis. (A) Consensus matrix for k = 2, illustrating the optimal clustering of samples. (B) UMAP plot showing the two-dimensional embedding of the re-clustered samples (Subgroup A and Subgroup B). (C) PCA plot demonstrating the separation of Subgroup A and Subgroup B along the first two principal components (PC1 and PC2). Heatmap (D) and box plot (E) of immune cell infiltration between the two re-clustered groups. Data were analyzed using the Wilcoxon test. *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001; ns, no significance.