Fig. 2
Construction of a HCC-associated MRGs signature utilizing the TCGA-LIHC cohort. (A) The volcano plot demonstrating differentially expressed genes between HCC and normal tissues using the TCGA-LIHC cohort. (B) The Venn diagram showing the intersection of HCC-associated DEGs with human mitochondria-associated genes. Lasso (C,D), univariate (E), and multivariate Cox regression analyses (F) were performed to screen and construct a MRGs signature in HCC. (G) Heat map showing correlation between members of MRGs. (H,I) Unpaired and paired analyses were performed to assess the differential expression of members of MRGs in HCC and normal tissues. (J) ROC curve demonstrating the accuracy of MRGs in diagnosing HCC tissue. (K) The scatterplot demonstrating the difference in survival time and number of deaths in HCC patients in the MRGs-high and -low groups. (L) Kaplan–Meier survival curve showing the difference in overall survival of HCC patients in the MRGs-high and -low groups. (M) Time-dependent ROC curves demonstrating the accuracy of MRGs in predicting 1-, 3-, and 5-year survival in HCC patients. **P < 0.01, ***P < 0.001.
