Fig. 2 | Scientific Reports

Fig. 2

From: NFIC suppressed the epithelial ovarian cancer via modulating the balance of PTEN/TGFβ1/EGR1/BRD4 and SP1/EZH2 induced Inhibition of TBX2/MMPs signaling

Fig. 2

NFIC inhibits the development of epithelial ovarian cancer, while TBX2 promotes the progression of epithelial ovarian cancer. A: Subcutaneous tumor transplantation experiment results in nude mice and statistical graphs of tumor volume and weight for the NC group, NFIC-OE group, NFIC-OE + TBX2-OE group, NFIC-KD group, NFIC-KD + PTEN-OE group, and NFIC-KD + PTEN-OE + TGFβ1-KD group; B: Subcutaneous tumor transplantation experiment results in nude mice and statistical graphs of tumor volume and weight for the NC group, and TBX2-OE group; C: Immunohistochemical staining results for the NC group, NFIC-OE group, NFIC-OE + TBX2-OE group, NFIC-KD group, NFIC-KD + PTEN-OE group, and NFIC-KD + PTEN-OE + TGFβ1-KD group, along with statistical graphs showing the expression levels of NFIC and TBX2. Data are expressed as mean ± standard deviation. N = 6; **P<0.01; nsP>0.05.

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