Fig. 1
From: Mild hypothermia attenuates hepatic ischemia-reperfusion injury by regulating FoxO1/PPARα pathway
PPARα expression decreased after OLT and correlates with clinical outcomes. (A) GO and KEGG pathways altered in pre- vs. post-OLT liver tissues. (B) Heatmap analysis of pre-vs. post-OLT group. (C) Volcano plot of differentially regulated genes, P < 0.05 were considered significant. (D) Representative images of HE and PPARα immunofluorescence image in pre- vs. post-OLT liver tissues, scale bar = 100 μm and their quantification results. (E,F) Change of PPARα mRNA and protein expression in the paired liver tissues. (G) The Pearson correlation analysis of PPARα and serum ALT/AST levels.
