Fig. 2 | Scientific Reports

Fig. 2

From: Comprehensive multi-omics and machine learning framework for glioma subtyping and precision therapeutics

Fig. 2

Molecular Subtype Characterization and Immune Landscape Analysis in Glioma (A). Heatmap showing immune pathway enrichment scores across GloMICS subtypes of glioma. (B). Heatmaps depicting transcriptional regulatory networks (TRN) and chromatin remodeling activities across GloMICS subtypes in glioma patients. (C). Heatmaps illustrating the immune landscape of glioma subtypes, focusing on immune checkpoint expression and tumor microenvironment (TME) infiltration. (D–E). Heatmaps generated by Nearest Template Prediction (NTP) analysis, classifying samples from both the CCGC and GEO cohorts into molecular subtypes based on TCGA-derived subtypes. (F–G). Survival analysis of across three subtypes in both the CCGC and GEO cohorts. (H–I). Consistency heatmaps comparing molecular subtypes assigned by Nearest Template Prediction (NTP) and partitioning around medoids (PAM) clustering in both the CCGC and GEO cohorts.

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