Table 1 Baseline clinical characteristics.
From: Contemporary outcomes in no-option chronic limb-threatening ischemia
Pathway 1 lack of target (N = 123) | Pathway 2 non-responders (N = 57) | All patients (N = 180) | |
|---|---|---|---|
Median age | 71.0 (61.0–78.0) | 68.0 (61.0–76.0) | 70.0 (61.0–78.0) |
Male sex—no. (%) | 82 (66.7%) | 38 (66.7%) | 120 (66.7%) |
Racea—no. (%) | |||
White | 71 (61.2%) | 25 (49.0%) | 96 (57.5%) |
Black or African Descent | 39 (33.6%) | 26 (51.0%) | 65 (38.9%) |
Asian | 5 (4.3%) | 0 (0%) | 5 (3.0%) |
American Indian or Alaska Native | 1 (0.9%) | 0 (0%) | 1 (0.6%) |
Unknown/Declined to state | 7 | 6 | 13 |
Ethnic group*—no. (%) | |||
Not Hispanic or Latino | 110 (90.2%) | 45 (84.9%) | 155 (88.6%) |
Hispanic or Latino | 12 (9.8%) | 8 (15.1%) | 20 (11.4%) |
Unknown/Declined to state | 1 | 4 | 5 |
Median BMI† | 27.5 (23.2–30.8) | 26.8 (23.0-30.4) | 27.4 (23.0-30.8) |
History | |||
Stroke—no. (%) | 23 (18.9%) | 9 (15.8%) | 32 (17.9%) |
Heart failure—no. (%) | 37 (31.1%) | 20 (38.5%) | 57 (33.3%) |
Smoking—no. (%) | 74 (61.2%) | 31 (57.4%) | 105 (60.0%) |
Current | 14 (11.6%) | 10 (18.5%) | 24 (13.7%) |
Past | 60 (49.6%) | 21 (38.9%) | 81 (46.3%) |
Unknown | 2 | 3 | 5 |
Diabetes mellitus—no. (%) | 93 (75.6%) | 44 (77.2%) | 137 (76.1%) |
Type I | 6 (4.9%) | 1 (1.8%) | 7 (3.9%) |
Type II | 87 (70.7%) | 43 (75.4%) | 130 (72.2%) |
Hypertension—no. (%) | 112 (91.1%) | 54 (94.7%) | 166 (92.2%) |
Dyslipidemia—no. (%) | 91 (75.2%) | 50 (89.3%) | 141 (79.7%) |
Hepatic insufficiency—no. (%) | 3 (2.5%) | 2 (3.5%) | 5 (2.8%) |
Renal disease—no. (%) | 61 (49.6%) | 31 (54.4%) | 92 (51.1%) |
Chronic kidney disease** | 28 (22.8%) | 13 (22.8%) | 41 (22.8%) |
End stage renal disease/dialysis | 30 (24.4%) | 15 (26.3%) | 45 (25.0%) |
Renal insufficiency | 3 (2.4%) | 3 (5.3%) | 6 (3.3%) |
Myocardial infarction—no. (%) | 30 (24.6%) | 17 (30.4%) | 47 (26.4%) |
Deep vein thrombosis—no. (%) | 15 (12.2%) | 7 (12.7%) | 22 (12.4%) |
Retinopathy—no. (%) | 15 (12.6%) | 3 (6.1%) | 18 (10.7%) |
Peripheral neuropathy—no. (%) | 57 (47.5%) | 21 (42.9%) | 78 (46.2%) |
Rutherford category‡—no. (%) | |||
5 | 70/121 (57.9%) | 36/51 (70.6%) | 106/172 (61.6%) |
6 | 51/121 (42.1%) | 15/51 (29.4%) | 66/172(38.4%) |
Previous intervention in target limb—no. (%) | |||
None (no-option) | 45 (36.6%) | 0 | 45 (25.0%) |
1 | 73 (59.3%) | 0 | 73 (40.6%) |
2 or more | 5 (4.1%) | 57 (100%) | 62 (34.4%) |
Ambulatory status | |||
No assistance needed | 21 (17.1%) | 6/56 (10.7%) | 27/179 (15.1%) |
Minimal assistance needed | 20 (16.3%) | 13/56 (23.2%) | 33/179 (18.4%) |
Walker assistance needed | 32 (26.0%) | 20/56 (35.7%) | 52/179 (29.1%) |
Wheelchair/non-ambulatory | 59 (40.7%) | 17/56 (30.4%) | 67/179 (37.4%) |
Wound status§ | |||
Open wound on limb | 89/122 (73.0%) | 43 (75.4%) | 132/179 (73.7%) |
Diagnosis of osteomyelitis | 21/122 (17.2%) | 12 (21.1%) | 33/179 (18.4%) |
Diagnosis of gangrene | 58/122 (47.5%) | 26 (45.6%) | 84/179 (46.9%) |
Treatment information | |||
Geographic region|| | |||
South | 59 (48.0%) | 37 (64.9%) | 96 (53.3%) |
Northeast/Mid-Atlantic | 50 (40.7%) | 8 (14.0%) | 58 (32.2%) |
Midwest | 10 (8.1%) | 10 (17.5%) | 20 (11.1%) |
West | 4 (3.3%) | 2 (3.5%) | 6 (3.3%) |
Referring physician | |||
Treating physician | 78 (64.5%) | 42 (75.0%) | 120 (67.8%) |
Emergency department | 1 (0.8%) | 0 | 1 (0.6%) |
Podiatrist | 13 (10.7%) | 5 (8.9%) | 18 (10.2%) |
Specialist | 21 (17.4%) | 8 (14.3%) | 29 (16.4%) |
Other | 8 (6.6%) | 1 (1.8%) | 9 (5.1%) |
Treating physician specialty | |||
Vascular surgery | 76 (61.8%) | 23 (40.4%) | 99 (55.0%) |
Interventional cardiology | 44 (35.8%) | 33 (57.9%) | 77 (42.8%) |
Podiatry | 3 (2.4%) | 1 (1.8%) | 4 (2.2%) |
