Table 4 Association between altitude per 500 and the severity of CSVD and MRI markers of CSVD among mid-high altitude and ultra-high altitude participants.

From: The association between altitude and cerebral small vessel disease burden in the Tibetan population: a cross-sectional study

 

Severity of CSVD

RSSI

LI

WMH

EPVS

OR

(95% CI)

P

OR

(95% CI)

P

OR

(95% CI)

P

OR

(95% CI)

P

OR (95% CI)

P

Among ultra-high altitude group

 Model 1

0.84 (0.61 ~ 1.16)

0.295

0.84 (0.47 ~ 1.48)

0.541

1.16 (0.78 ~ 1.73)

0.473

0.78 (0.58 ~ 1.06)

0.111

0.87 (0.56 ~ 1.35)

0.525

 Model 2

0.98 (0.68 ~ 1.41)

0.622

1.00 (0.53 ~ 1.89)

0.998

1.31 (0.84 ~ 2.03)

0.235

0.99 (0.69 ~ 1.40)

0.935

1.10 (0.62 ~ 1.63)

0.987

Among mid-high altitude group

 Model 1

0.97 (0.44 ~ 2.15)

0.944

-

-

-

-

0.56 (0.26 ~ 1.21)

0.140

4.64 (0.49 ~ 43.59)

0.179

 Model 2

0.77 (0.28 ~ 2.12)

0.618

-

-

-

-

0.37 (0.10 ~ 1.28)

0.116

1.56 (0.05 ~ 51.96)

0.802

  1. Model 1: unadjusted for any covariates.
  2. Model 2: adjusted for age, sex, smoking status, alcohol use, hemoglobin, hypertension, diabetes, CAD, stroke, and hyperlipidemia.
  3. CSVD cerebral small-vessel disease, RSSI recent small subcortical infarcts, LI lacunar infarction, WMH white matter hyperintensities, EPVS enlarged perivascular space, OR odds ratio, CI confidence interval, MRI magnetic resonance imaging, CAD coronary artery disease, Ref reference.
  4. -: The association between altitude and RSSI and LI was not analyzed in the mid-high altitude group due to only five cases of RSSI and only nine cases of LI.
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