Fig. 2 | Scientific Reports

Fig. 2

From: Hepatocyte FoxO1 depletion exacerbates hepatic inflammation in MASH by targeting cystathionine γ-lyase

Fig. 2

The effects of FoxO1 on hepatic inflammation in vitro were detected by transcriptome sequencing. (A) FoxO1 gene knock-out efficiency was detected by Western blot. (B) Principal component analysis (PCA) revealed the relationships between samples in the LPS-induced WT and FoxO1-KO groups. (C) A volcano plot showed differentially expressed genes (DEGs), along with their statistical significance values and fold changes. Up-regulated or down-regulated DEGs are shown in red or yellow dots, respectively. (D) A heat map-based representation of inflammation-related DEGs in LPS-treated WT and FoxO1-KO cells.

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