Fig. 7
From: Impaired myogenesis in limb girdle muscular dystrophy type 2B
Dysferlin knocking-out reproduces the impaired myogenic phenotype observed in the LGMD2B myotubes. (A) Immunofluorescence staining against anti-alpha-actinin antibody shows smaller myotubes in the DYSF−/− cell line. (B) Mean and SD values of myotube area showing that the size of the DYSF−/− myotubes are significantly smaller than those from the control cell line. (C) Proportion of myotube’s size classes, indicating that over 80% measured myotubes from the DYSF−/− cell lines are smaller than 50,000 μm², while about half of the myotubes from the control cell line are larger than 50,000 μm².
