Fig. 6 | Scientific Reports

Fig. 6

From: Comprehensive analysis of Mendelian randomization and scRNA-seq identify key prognostic genes and relevant functional roles in colorectal cancer

Fig. 6

Exploring the biological significance of immune cell infiltration pattern. (A) Stacked bar plots depict the relative proportions of the 22 tumor-infiltrating immune cell subtypes in each sample. (B) Associations between 22 tumor-infiltrating immune cells. (C) The number of active memory CD4 T cells, resting NK cells, M0 macrophages, M1 macrophages, and mast cells was significantly increased in CRC patients compared with the normal group. (D) The lollipop chart showed that MMRN1 was strongly positively correlated with M2 macrophages, static mast cells and naive B cells, and significantly negatively correlated with activated mast cells, M0 macrophages and static NK cells. (E) The lollipop chart showed that SLC6A19 was significantly positively correlated with static mast cells, plasma cells and naive B cells, and significantly negatively correlated with M0 macrophages, static NK cells and activated mast cells.

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