Fig. 8 | Scientific Reports

Fig. 8

From: Comprehensive analysis of Mendelian randomization and scRNA-seq identify key prognostic genes and relevant functional roles in colorectal cancer

Fig. 8

Enrichment analysis of key gene specific signaling pathways. (A) The GSEA results of MMRN1 showed significant enrichment of the oxytocin signaling pathway, relaxin signaling pathway and TGF-β signaling pathway, and showed high activity in CRC group. (B) Oxytocin signaling pathway, relaxin signaling pathway and TGF-β signaling pathway were enriched gene sets, DCN, GREM1 and other genes were more prominent. (C) GSEA results of SLC6A19 showed significant enrichment of galactose metabolism, retinol metabolism and tyrosine metabolism pathways, and showed high activity in CRC group. (D) Gene sets enriched in the pathways of galactose metabolism, retinol metabolism and tyrosine metabolism, with ADH1C and other genes prominent. (E) The GSVA pathway enrichment analysis of MMRN1 showed significant enrichment of IL2/STAT5 signaling pathway, IL6/JAK/STAT3 signaling pathway and Notch signaling pathway. (F) The GSVA pathway enrichment analysis of SLC6A19 showed significant enrichment of bile acid metabolism, xenobiotic metabolism, and allograft rejection pathways.

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