Table 1 Clinical characteristics of ERM eyes at baseline and 6-month follow-up.

From: Ectopic inner foveal layer as post pars plana vitrectomy prognostic predictor in eyes with idiopathic epiretinal membrane

 

Stage 1 ERM (n = 13)

Stage 2 ERM (n = 89)

Stage 3 ERM (n = 177)

Stage 4 ERM (n = 75)

P-value

Male/female

6/7

30/59

46/131

31/44

0.059a

Age (years)

66.9 ± 6.4 (59.0 ~ 76.0)

68.1 ± 6.9 (49.0 ~ 78.0)

67.1 ± 8.0 (50.0 ~ 89.0)

64.8 ± 7.6 (43.0 ~ 83.0)

0.004b

Pre-operative BCVA (logMAR)

0.50 ± 0.17 (0.22 ~ 0.70)

0.54 ± 0.26 (0.22 ~ 1.52)

0.66 ± 0.28 (0.22 ~ 1.40)

0.81 ± 0.27 (0.30 ~ 1.40)

< 0.001b

Pre-operative BCVA (decimal, for reference)

0.34 ± 0.15 (0.20 ~ 0.60)

0.33 ± 0.14 (0.03 ~ 0.60)

0.26 ± 0.14 (0.04 ~ 0.60)

0.18 ± 0.10 (0.04 ~ 0.50)

–

Pre-operative CFT (µm)

269 ± 85 (179 ~ 401)

391 ± 63 (253 ~ 520)

489 ± 77 (333 ~ 734)

616 ± 69 (454 ~ 776)

< 0.001b

Pre-operative ONL thickness (µm)

162 ± 61 (90 ~ 233)

248 ± 57 (81 ~ 360)

253 ± 65 (139 ~ 475)

229 ± 82 (61 ~ 404)

< 0.001b

Pre-operative EIFL thickness (µm)

–

–

160 ± 72 (60 ~ 397)

313 ± 119 (129 ~ 556)

< 0.001c

Pre-operative ME

3/13 (23.1%)

27/89 (30.3%)

63/177 (35.6%)

62/75 (82.7%)

< 0.001a

Pre-operative EZ disruption

0/13 (0.0%)

33/89 (37.1%)

42/177 (23.7%)

13/75 (17.3%)

0.003a

Pre-operative “cotton ball” sign

0/13 (0.0%)

41/89 (46.1%)

69/177 (39.0%)

8/75 (10.7%)

< 0.001a

Baseline DRIL level

 No DRIL

10/13 (76.9%)

27/89 (30.3%)

28/177 (15.8%)

0/75 (0.0%)

 

 Mild DRIL

3/13 (23.1%)

62/89 (69.7%)

143/177 (80.8%)

12/75 (16.0%)

 Severe DRIL

0/13 (0.0%)

0/89 (0.0%)

6/177 (3.4%)

63/75 (84.0%)

6-month BCVA (logMAR)

0.40 ± 0.12 (0.30 ~ 0.52)

0.17 ± 0.14 (0.00 ~ 0.30)

0.40 ± 0.24 (0.09 ~ 1.00)

0.44 ± 0.30 (0.00 ~ 1.30)

< 0.001b

6-month BCVA (decimal, for reference)

0.59 ± 0.26 (0.30 ~ 1.00)

0.60 ± 0.24 (0.06 ~ 1.00)

0.26 ± 0.14 (0.04 ~ 0.60)

0.18 ± 0.15 (0.04 ~ 0.50)

–

6-month CFT (µm)

387 ± 20 (365 ~ 412)

378 ± 102 (243 ~ 468)

424 ± 68 (223 ~ 568)

429 ± 102 (318 ~ 796)

< 0.001b

6-month ONL thickness (µm)

198 ± 18 (168 ~ 218)

217 ± 51(149 ~ 254)

220 ± 44 (118 ~ 295)

212 ± 38 (143 ~ 282)

0.001b

6-month EIFL thickness (µm)

102 ± 9 (92 ~ 115)

128 ± 89 (47 ~ 246)

111 ± 43 (0 ~ 222)

139 ± 95 (72 ~ 535)

0.291b

6-month logMAR BCVA decrease

0.24 ± 0.25 (0.00 ~ 0.60)

0.27 ± 0.21 (− 0.17 ~ 0.92)

0.34 ± 0.25 (− 0.30 ~ 1.18)

0.36 ± 0.29 (− 0.30 ~ 1.00)

0.008c

6-month CFT reduction (µm)

− 57 ± 38 (− 196 ~ 10)

71 ± 80 (− 100 ~ 291)

106 ± 90 (− 88 ~ 343)

205 ± 84 (− 20 ~ 349)

< 0.001c

  1. ERM epiretinal membrane; BCVA best corrected visual acuity, CFT central foveal thickness, ONL outer nuclear layer, EIFL ectopic inner foveal layer, ME macular edema, EZ ellipsoid zone, DRIL disorganization of the retinal inner layers.
  2. aFisher’s exact test; bKruskal–Wallis H test; cMann–Whitney U test.
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