Fig. 8 | Scientific Reports

Fig. 8

From: Integrating bulk and single cell sequencing data to identify prognostic biomarkers and drug candidates in HBV associated hepatocellular carcinoma

Fig. 8

Cell-cell Communications analysis based on HBV-HCC single-cell RNA-sequencing. (A) The number and strength of cell interaction mediated by individual. signal pathways in normal and HBV-HCC groups. (B) Circle plots illustrate the changes in the number and strength of intercellular communications. Red indicates increased signaling in HBV-HCC compared to the normal group, while blue represents decreased signaling. (C) Heatmaps displayed the overall (both outgoing and incoming) signal flows of each cell population. (D) SPP1 signal pathway in normal and HBV-HCC groups. (E) ApoA signal pathway in normal and HBV-HCC groups. (F) Bubble map of cell–cell communication mediated by individual signaling axes, with the horizontal axis showing the cell class that initiates and receives the signal, and the vertical axis showing receptor-ligand pairs of the signaling pathway.

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