Fig. 1
From: Hyperglycemia-induced mitochondrial abnormalities in autonomic neurons via the RAGE axis
Hyperglycemia induces changes in mitochondrial ultrastructure in WT but not in RAGE KO mice. A-B, Transmission electron microscopy (TEM) images were obtained from the SCG of WT (A-B) and RAGE KO (C-D) mice. Mice were either control (CTL, A&C) and STZ-induced diabetic (STZ; B&D). Insets show the magnified area of interest outlined in red. N: nucleus; Cyt: cytoplasm; and M: plasma membrane. Scale bars: 1 μm (A-B), 2 μm (C-D), and for the inset panels 0.2 and 0.4 μm WT and RAGE KO, respectively. (N = 5 for WT CTL, WT STZ and RAGE KO CTL; and N = 4 for RAGE KO STZ).
