Fig. 3
From: Hyperglycemia-induced mitochondrial abnormalities in autonomic neurons via the RAGE axis
High glucose treatment in vitro caused a reduction in the size of stationary mitochondria in SCG neurons from WT but not from RAGE KO mice. A, Representative examples of epifluorescence images captured from neurites of SCG neurons expressing Mito-eGFP from either WT or RAGE KO mice exposed to control (CTL) or high glucose (HG) conditions. Images are oriented with the cell body to the left and the neurite tip to the right. Scale bar = 20 μm. B-C, Quantification of the mitochondrial size from mobile and stationary organelles in SCG cultures from WT (B) and RAGE KO (C) mice. Means were statistically compared by One-Way ANOVA; *** p < 0.001. (N = 134 WT CTL, 156 WT HG, 70 RAGE KO CTL, and 161 RAGE KO HG).
