Fig. 4
From: Hyperglycemia-induced mitochondrial abnormalities in autonomic neurons via the RAGE axis
Mitochondrial fragmentation in high glucose was not prevented by the selective RAGE inhibitor FPS-ZM1. A, Representative examples of epifluorescence images captured from neurites of SCG neurons labeled with MitoTracker Green in either WT or RAGE KO mice, or in WT mice incubated with the selective RAGE inhibitor (RI) FPS-ZM1 for 72 h before measurement. All groups were maintained in control (CTL) or high glucose (HG) conditions. Scale bar = 10 μm. B, Quantification of the mitochondrial size in SCG cultures from WT and RAGE KO mice. Means were statistically compared using one-way ANOVA, F (5, 1908) = 13.87; *** p < 0.0001; **** p < 0.0001. (N = 353 WT CTL, 332 WT CTL + RI, 359 WT HG, 282 WT HG + RI, 297 RAGE KO CTL, 413 RAGE KO HG).
