Fig. 5
From: Hyperglycemia-induced mitochondrial abnormalities in autonomic neurons via the RAGE axis
RAGE interferes with retrograde mitochondrial transport in high glucose conditions. A, Kymograph analysis from movies neurites of SCG neurons expressing Mito-eGFP (CTL and HG) from WT mice. B, Quantification of the proportion of anterograde (Anter), retrograde (Retro), and stationary (Stat) mitochondria within neurites. C, Mitochondrial density per micron. D-E, Kymographs analysis and quantification of parameters as in A-C in cultured SCG neurons from RAGE KO mice. Scale bar = 20 μm. Means were statistically compared by One-Way ANOVA; * p < 0.05. (N = 64 WT CTL, 37 WT HG, 23 RAGE KO CTL, and 22 RAGE KO HG).
