Fig. 6
From: Hyperglycemia-induced mitochondrial abnormalities in autonomic neurons via the RAGE axis
RAGE contributes to mitochondrial ATP production in SCG neurons exposed to high glucose. Quantification of mitochondrial ATP (mATP) production in media containing control (CTL) or high glucose (HG) in cultured neurons from WT and RAGE KO mice. Neurons from WT mice were also incubated with the RAGE inhibitor (RI) FPS-ZM1 in both experimental conditions. Means were statistically compared by One-Way ANOVA– (F5,51 = 6.014); ** p < 0.001. (N = 12 WT CTL, 11 WT CTL + RI, 11 WT HG, 12 WT HG + RI, 8 RAGE CTL, 8 RAGE HG).
