Table 1 Characteristics of VEGFR-TKI-related tees from the FAERS database.
Characteristics | ATE (N = 1564) | VTE (N = 1124) | Total (N = 2688) | P value |
|---|---|---|---|---|
Sex | ||||
 Male | 918 (58.70%) | 668 (59.43%) | 1586 (59.00%) | 0.177 |
 Female | 474 (30.31%) | 387 (34.43%) | 861 (32.03%) | |
 Missing | 172 (11.00%) | 69 (6.14%) | 241 (8.97%) | |
Age | ||||
 Mean (SD) | 65.55 (11.07) | 63.09 (12.75) | 64.46 (11.90) | < 0.001 |
 Median [Q1, Q3] | 66 [59,73] | 64 [56,72] | 65 [58,73] | |
 Missing | 426 (27.24%) | 220 (19.57%) | 646 (24.03%) | |
Age group (years) | ||||
 < 18 | 2 (0.13%) | 7 (0.62%) | 9 (0.33%) | < 0.001 |
 18–64 | 479 (30.63%) | 462 (41.10%) | 941 (35.01%) | |
 65–74 | 421 (26.92%) | 273 (24.29%) | 694 (25.82%) | |
 ≥ 75 | 236 (15.09%) | 162 (14.41%) | 398 (14.81%) | |
 Missing | 426 (27.24%) | 220 (19.57%) | 646 (24.03%) | |
Indication | ||||
 Renal cell carcinoma | 248 (17.46%) | 132 (12.74%) | 380 (15.47%) | 0.025 |
 Hepatocellular carcinoma | 122 (8.59%) | 90 (8.69%) | 212 (8.63%) | |
 Thyroid cancer | 79 (5.56%) | 44 (4.25%) | 123 (5.01%) | |
 Gastrointestinal stromal tumor | 47 (3.31%) | 23 (2.22%) | 70 (2.85%) | |
 Other | 924 (65.07%) | 747 (72.10%) | 1671 (68.04%) | |
Reporting country | ||||
 US | 611 (39.07%) | 439 (39.06%) | 1050 (39.06%) | < 0.001 |
 JP | 171 (10.93%) | 139 (12.37%) | 310 (11.53%) | |
 FR | 161 (10.29%) | 86 (7.65%) | 247 (9.19%) | |
 DE | 60 (3.84%) | 56 (4.98%) | 116 (4.32%) | |
 IT | 67 (4.28%) | 65 (5.78%) | 132 (4.91%) | |
 CN | 58 (3.71%) | 14 (1.25%) | 72 (2.68%) | |
 IN | 39 (2.49%) | 5 (0.44%) | 44 (1.64%) | |
 CA | 22 (1.41%) | 26 (2.31%) | 48 (1.79%) | |
 Other | 350 (22.38%) | 278 (24.73%) | 628 (23.36%) | |
 Missing | 25 (1.60%) | 16 (1.42%) | 41 (1.53%) | |
Outcome | ||||
 Disability | 35 (1.61%) | 29 (1.79%) | 64 (1.69%) | 0.923 |
 Hospitalization - initial or prolonged | 915 (42.11%) | 680 (41.98%) | 1595 (42.05%) | |
 Life-threatening | 171 (7.87%) | 118 (7.28%) | 289 (7.62%) | |
 Death | 334 (15.37%) | 243 (15.00%) | 577 (15.21%) | |
 Other | 718 (33.04%) | 550 (33.95%) | 1268 (33.43%) | |
