Fig. 4 | Scientific Reports

Fig. 4

From: Curcumin’s dual effect on pyroptosis and autophagy in metabolic- associated fatty liver disease: a potential therapeutic strategy

Fig. 4

(A) Quantitative RT-PCR analysis of BECN1 gene expression in liver tissues. A significant downregulation was observed in Group II, suggesting impaired autophagy. Curcumin (Group III) partially restored BECN1 expression, supporting its role in autophagy modulation. Data are mean ± SD (n = 6); *P < 0.05. (B) Western blot analysis of P62 protein levels in liver tissues. Increased P62 expression in Group II indicates autophagic flux impairment. Curcumin treatment (Group III) reduced P62 levels, suggesting autophagy restoration. Representative blots shown; quantitative data presented as mean ± SD. *P < 0.05. Data shown are from n = 2 biological replicates, with consistent results across replicates. Full-length, unprocessed blots are available in Supplementary Figure S2.

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