Fig. 5

Histological assessment of liver tissue structure and fibrosis. Figure 5 (1): Microscopic images of H&E-staining sections from Group I. (A) Normal hepatic architecture, featuring a central vein (star) surrounded by cords of hepatocytes, separated by distinct blood sinusoids (arrow). The cells exhibit granular, acidophilic cytoplasm with large, round vesicular nuclei, nearly are being binucleated (arrowhead). (B) Highlights the portal area (arrow), containing a branch of the portal vein (p), the hepatic artery (a), and the bile duct (b) (Magnification X400). Figure 5 (2): Microscopic images of the H&E-staining section of group II. (A) Dilated central vein surrounded by mononuclear cellular infiltration (star), large cytoplasmic vacuoles of many hepatocytes (arrow), and irregular shrunken hepatocytes with deeply stained pyknotic nuclei (arrowhead). (B) Dilated blood sinusoids (star) and heavy mononuclear cellular infiltration (arrow). (C) Hepatocytes with large cytoplasmic vacuoles (arrow) and others are shrunken and irregular with pyknotic nuclei (arrowhead). (D) Portal area with dilated branches of the portal vein (p), hepatic artery (a), and bile duct (b). Heavy mononuclear cellular infiltration (arrow). (Magnification X400). Figure 5 (3): Microscopic images of the H&E-staining section of group III. (A) Hepatocyte architecture nearly like group I (arrow). Notice mild dilation of the central vein and the blood sinusoids (stars). (B) Portal area elements almost like group I (arrow). (Magnification X400).