Table 1 Pharmacokinetic parameters for C57BL/6 andhiFcRn mice.

From: Advanced human FcRn knock-in mice for pharmacokinetic profiling of therapeutic antibodies

  1. t1/2, terminal half-life (β-phase); Cmax, maximum concentration; AUCinf, area under the concentration-time curve from administration to infinity; AUC%Extrap, percentage of the extrapolated area under the curve relative to the total area under the curve; CL, clearance. Dose and administration routes, single intravenous (i.v.) bolus at 5 mg/kg (n = 5/group) for wild-type and hiFcRn mice.
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