Table 1 Baseline characteristics between mannitol and no mannitol.
Variables | Total (n = 1042) | Mannitol (n = 115) | No mannitol (n = 927) | P value |
|---|---|---|---|---|
Age(yr), Mean ± SD | 67.9 ± 15.6 | 63.5 ± 15.9 | 68.5 ± 15.5 | 0.001 |
Sex, n (%) | 0.067 | |||
Female | 478 (45.9) | 62 (53.9) | 416 (44.9) | |
Male | 564 (54.1) | 53 (46.1) | 511 (55.1) | |
BMI (kg/m2), Mean ± SD | 28.5 ± 7.6 | 28.6 ± 7.7 | 28.3 ± 6.6 | 0.775 |
AKI_ stage, n (%) | 0.403 | |||
1 | 212 (20.4) | 185 (20.0) | 27 (20.4) | |
2 | 519 (49.8) | 462 (49.8) | 57 (49.6) | |
3 | 311 (29.8) | 280 (30.2) | 31 (27) | |
Glasgow Coma Score, Mean ± SD | 12.7 ± 3.0 | 12.0 ± 4.0 | 12.8 ± 2.9 | 0.011 |
Severity of illness | ||||
SOFA, Median (IQR) | 3.0 (1.0, 4.0) | 3.0 (1.0, 4.0) | 3.0 (2.0, 5.0) | 0.034 |
SAPSII, Median (IQR) | 33.2 ± 11.8 | 33.1 ± 11.7 | 34.3 ± 12.6 | 0.306 |
Charlson Index, Median (IQR) | 5.7 ± 2.5 | 5.7 ± 2.5 | 5.0 ± 2.1 | 0.002 |
Comorbidities, n(%) | ||||
Hypertension | 707 (67.9) | 638 (68.8) | 69 (60.0) | 0.056 |
Diabetes | 222 (21.3) | 200 (21.6) | 22 (19.1) | 0.546 |
Myocardial infarction | 51 ( 4.9) | 42 (4.5) | 9 (7.8) | 0.122 |
Heart failure | 135 (13.0) | 115 (12.4) | 20 (17.4) | 0.133 |
Cirrhosis | 45 ( 4.3) | 39 (4.2) | 6 (5.2) | 0.624 |
Vital signs | ||||
HR(beats min-1), Mean ± SD | 81.2 ± 14.2 | 81.2 ± 14.1 | 81.5 ± 14.9 | 0.820 |
Map(mmHg), Mean ± SD | 73.3 ± 8.7 | 72.8 ± 8.4 | 77.0 ± 9.7 | < 0.001 |
RR (beats min-1), Mean ± SD | 19.1 ± 3.2 | 19.1 ± 3.3 | 19.2 ± 3.0 | 0.730 |
SpO2(%), Mean ± SD | 96.9 ± 2.0 | 96.8 ± 2.0 | 97.8 ± 1.8 | < 0.001 |
Temperature(℃), Mean ± SD | 37.0 ± 0.4 | 37.0 ± 0.4 | 37.1 ± 0.4 | 0.023 |
Laboratory tests | ||||
WBC count(K/uL), Median (IQR) | 10.3 (8.4, 13.1) | 10.1 (8.3, 13.0) | 11.4 (9.6, 13.8) | 0.002 |
RBC count(m/uL), Mean ± SD | 4.0 ± 0.8 | 4.0 ± 0.8 | 4.0 ± 0.8 | 0.778 |
Platelet count(K/uL), Median (IQR) | 214.5 ± 80.5 | 216.3 ± 81.3 | 200.3 ± 72.5 | 0.045 |
Hemoglobin(g/dL), Mean ± SD | 12.2 ± 2.0 | 12.2 ± 2.0 | 12.0 ± 1.9 | 0.392 |
Sodium(mEq/L), Mean ± SD | 140.6 ± 5.1 | 140.4 ± 5.1 | 141.9 ± 4.8 | 0.003 |
Potassium(mEq/L), Mean ± SD | 4.0 ± 0.4 | 4.0 ± 0.5 | 3.9 ± 0.4 | 0.343 |
Calcium (mg/dL), Mean ± SD | 8.7 ± 0.6 | 8.7 ± 0.6 | 8.5 ± 0.6 | 0.003 |
BUN (mg/dL), Mean ± SD | 14.6 (11.8, 20.0) | 15.0 (12.0, 20.0) | 13.5 (10.0, 17.8) | 0.009 |
Creatinine(mg/dL), Mean ± SD | 0.8 (0.7, 1.0) | 0.8 (0.7, 1.0) | 0.8 (0.7, 1.0) | 0.100 |
Treatment | ||||
Mannitol medication information | ||||
First medication time (relative to ICU admission) (days), Median (IQR) | 0.7 (0.3, 1.9) | |||
Total dose drug(grams), Median (IQR) | 100.0 (75.0, 200.0) | |||
Daily medication frequency | 1.0 (1.0, 3.5) | |||
Total time of medication | 1.4 (0.0, 3.0) | |||
Mechanical ventilation, n (%) | 365 (35.0) | 68 (59.1) | 297 (32) | < 0.001 |
Ventilation duration(hours), Median (IQR) | 44.7 (16.0, 139.0) | 83.9 (23.0, 156.2) | 38.0 (16.0, 131.8) | 0.027 |
Surgery, n (%) | 20 (1.9) | 7 (6.1) | 13 (1.4) | 0.004 |
Outcome | ||||
28-day mortality, n (%) | 261 (25.0) | 58 (50.4) | 203 (21.9) | < 0.001 |
In-hospital mortality, n (%) | 205 (19.7) | 55 (47.8) | 150 (16.2) | < 0.001 |
