Table 2 Comparison of ReHo and fALFF values between MADIs at stage I, stage II and HCs.

From: Abnormal regional brain activity associated with relapse in early abstinent methamphetamine-dependent individuals

Brain regions (AAL)	Peak MNI coordinates			Clusters	Peak T values
Brain regions (AAL)	x	y	z	Clusters	Peak T values
ReHo
*MADIs at Stage I vs. HCs*
Left superior parietal gyrus	−27	−51	57	34	−4.19
Left middle temporal gyrus	−57	−15	−3	49	−4.65
Left inferior temporal gyrus	−42	−18	−27	42	5.21
Right inferior temporal gyrus	39	−9	−33	116	5.01
Right insula	42	−15	0	20	4.91
*MADIs at Stage II vs. HCs*
Left middle cingulate gyrus	−6	−39	48	13	−3.42
Left postcentral gyrus	−51	−12	27	36	−4.10
Left superior temporal gyrus	−60	−12	6	27	−4.07
Left middle occipital gyrus	−42	−81	9	28	−4.13
Left cuneus	−12	−84	21	18	−3.74
Right postcentral gyrus	48	−9	39	66	−4.36
Right superior temporal gyrus	66	−42	21	15	−4.62
Right calcarine fissure	15	−84	15	73	−3.85
Left opercular part of inferior frontal gyrus	36	9	12	20	3.49
Left caudate	−6	12	−6	17	3.35
Left hippocampus	−27	−30	−6	42	5.07
Right precuneus	21	−54	24	27	4.21
Right hippocampus	39	−9	−27	156	5.07
Right parahippocampal gyrus	30	−33	−9	17	3.57
*MADIs at Stage II vs. Stage I*
Left inferior temporal gyrus	−54	−18	−24	19	−4.21
Left fusiform gyrus	−24	−39	−15	22	3.72
Left olfactory	0	18	−6	13	4.11
fALFF
*MADIs at Stage I vs. HCs*
Right precentral gyrus	42	−24	63	13	−4.64
Left putamen	−21	3	−3	124	4.98
Right putamen	27	9	0	97	5.16
*MADIs at Stage II vs. HCs*
Left middle cingulate gyrus¹	−9	−42	36	76	−4.23
Left middle cingulate gyrus²	−6	−42	48	16	−4.77
Left precuneus	−9	−42	69	14	−3.94
Left postcentral gyrus	−54	−12	39	22	−4.32
Left paracentral lobule	−3	−30	72	46	−4.43
Right postcentral gyrus	48	−9	33	25	−4.46
Right superior occipital gyrus	21	−81	39	15	−3.69
Right angular gyrus	42	−69	39	28	−4.11
Right lingual gyrus	9	−54	0	29	−4.58
Left parahippocampal gyrus	−30	−6	−30	13	3.93
Left putamen	−21	15	3	358	7.12
Left thalamus	−12	−15	6	18	3.93
Right opercular part of inferior frontal gyrus	42	18	9	14	4.22
Right anterior cingulate gyrus	9	27	24	16	4.65
Right putamen	27	12	0	318	6.51
Right hippocampus	30	−6	−21	26	4.76
*MADIs at Stage II vs. Stage I*
Left paracentral lobule	−3	−30	72	20	−4.40
Right postcentral gyrus	48	−9	33	30	−5.68
Left opercular part of inferior frontal gyrus	−36	15	12	13	4.52
Left caudate nucleus	−15	18	3	22	5.05
Right caudate nucleus	18	21	3	21	4.54

MA: methamphetamine; MADIs: MA-dependent individuals; MADIs at Stage I: MADIs when they were abstinent from MA; MADIs at Stage II: MADIs when they relapsed to MA; HCs: healthy controls; ReHo: regional homogeneity; fALFF: fractional amplitude of low-frequency fluctuation; AAL: anatomic automatic labeling; MNI: Montreal Neurological Institute; x, y and z: the coordinates of peak voxel of each cluster in the MNI space. The significant differences were set at P < 0.005 (a minimum cluster size of 13 voxels, corrected by the AlphaSim program in REST software).

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Table 2 Comparison of ReHo and fALFF values between MADIs at stage I, stage II and HCs.

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