Fig. 3 | Scientific Reports

Fig. 3

From: Hydroxysafflor Yellow A modulation of metabolite networks and inhibition of JAK2/STAT1 pathway in sepsis

Fig. 3

Metabolomics analysis of metabolic profiling changes in lung tissue. (A) DEMs between CLP vs. Sham and between CLP vs. HYSA300 groups using OPLS-DA, with screening criteria of VIP > 1 and P < 0.05. (B) Volcano plots of DEMs between CLP and Sham groups. (C) Volcano plot of DEMs between CLP and HYSA300 groups. (D) Venn diagram of common DEMs among the three groups. (E) Pathway analysis of common DEMs. (F) Common DEMs that can be reverted after HYSA treatment. (G) Heat map of common DEMs that can be reverted after HYSA treatment. Data are presented as mean ± SD. ***P < 0.001, **P < 0.01 and *P < 0.05 vs. the CLP group. n = 8–10 mice per group.

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