Table 2 The information of metabolites in lung profiles by using UPLC-MS/MS.(n = 8–10).
Number | Component | Formula | m/z | CLP vs.Sham | HYSA300 vs. CLP |
|---|---|---|---|---|---|
1 | L-Histidinol | C6H11N3O | 124.09 | ↓ | ↑ |
2 | 2z-Penten-1-Ol | C5H10O | 104.11 | ↑ | ↓ |
3 | 8s-Hete | C20H32O3 | 319.23 | ↓ | ↑ |
4 | L-Leucine | C6H13NO2 | 132.10 | ↑ | ↓ |
5 | Stearoylcarnitine | C25H49NO4 | 428.37 | ↑ | ↓ |
6 | 3-Hydroxyoctadecanoylcarnitine | C25H49NO5 | 426.36 | ↑ | ↓ |
7 | Photinus Luciferin | C11H8N2O3S2 | 281.00 | ↑ | ↓ |
8 | 2-N,2-N-Dibutylbenzene-1,2-Diamine | C14H24N2 | 243.18 | ↑ | ↓ |
9 | 3-Butenenitrile | C4H5N | 85.08 | ↓ | ↑ |
10 | (10z,12z)-Octadeca-10,12-Dienoylcarnitine | C25H45NO4 | 424.34 | ↑ | ↓ |
11 | 3-Amino-2-Naphthoic Acid | C11H9NO2 | 205.10 | ↑ | ↓ |
12 | 21-Hdha | C22H32O3 | 343.23 | ↓ | ↑ |
13 | 9,12,15-Octadecatrienal | C18H30O | 280.26 | ↑ | ↓ |
14 | N, N’-Diacetylhydrazine | C4H8N2O2 | 99.06 | ↓ | ↑ |
15 | Thiabendazole | C10H7N3S | 202.04 | ↑ | ↓ |
16 | L-Proline | C5H9NO2 | 116.07 | ↑ | ↓ |
17 | 3-Hydroxy-11z-Octadecenoylcarnitine | C25H47NO5 | 442.35 | ↑ | ↓ |
18 | Alpha-Carboxyethylhydroxychroman | C16H22O4 | 279.16 | ↑ | ↓ |
19 | Niacinamide | C6H6N2O | 123.06 | ↑ | ↓ |
20 | 15s-Hetre | C20H34O3 | 321.24 | ↓ | ↑ |
21 | L-Argininium(1+) | C6H15N4O2+ | 193.15 | ↓ | ↑ |
22 | PS(20:4(5Z,8Z,11Z,14Z)/0:0) | C26H44NO9P | 546.28 | ↑ | ↓ |
23 | Hydantoin | C3H4N2O2 | 101.03 | ↓ | ↑ |
24 | N-Methylhydantoin | C4H6N2O2 | 115.05 | ↓ | ↑ |
25 | 2,4-Diamino-Butyric Acid | C4H10N2O2 | 101.07 | ↓ | ↑ |
26 | PS(22:6(4Z,7Z,10Z,13Z,16Z,19Z)/0:0) | C28H44NO9P | 570.28 | ↑ | ↓ |
27 | L-Arginine | C6H14N4O2 | 175.12 | ↑ | ↓ |
28 | 1-Methylhistamine | C6H11N3 | 126.10 | ↓ | ↑ |
29 | Piperidine | C5H11N | 86.10 | ↑ | ↓ |
30 | 2,6-Dihydroxy-3-Cyanopyridine | C6H4N2O2 | 154.06 | ↓ | ↑ |
31 | 3-Propyl-1 h-Pyrazole | C6H10N2 | 128.12 | ↓ | ↑ |
32 | S-(2-Benzothiazolyl)Cysteine | C10H10N2O2S2 | 235.00 | ↑ | ↓ |
33 | 25-Hydroxyvitamin D3-26,23-Lactol | C27H42O4 | 448.34 | ↑ | ↓ |
34 | Phosphate | H3O4P | 96.97 | ↑ | ↓ |
35 | Gly-Pro-Gly-Arg-Ala-Phe | C27H41N9O7 | 586.31 | ↑ | ↓ |
36 | 5’-Methylthioadenosine | C11H15N5O3S | 298.10 | ↑ | ↓ |
37 | L-Allothreonine | C4H9NO3 | 120.07 | ↑ | ↓ |
38 | (6z)-Hexadecenoylcarnitine | C23H43NO4 | 398.33 | ↑ | ↓ |
39 | 5-Phenyl-1,3-Pentadiyne | C11H8 | 121.04 | ↑ | ↓ |
40 | Piperazine | C4H10N2 | 87.09 | ↓ | ↑ |
41 | PG(13:0/16:0) | C35H69O10P | 661.45 | ↓ | ↑ |
42 | 2-Chloro-L-Phenylalanine | C9H10ClNO2 | 198.03 | ↑ | ↓ |
43 | 2-Aminobenzimidazole | C7H7N3 | 151.10 | ↓ | ↑ |
44 | 2s-Amino-3-Oxo-Butanoic Acid | C4H7NO3 | 100.04 | ↓ | ↑ |
45 | 4-Aminobenzamidine | C7H9N3 | 153.11 | ↓ | ↑ |
46 | 1-(2-Hydroxyethyl)−2-Hydroxymethyl-5-Nitroimidazole | C6H9N3O4 | 232.06 | ↑ | ↓ |
47 | Methyl 14-Methyl-8-Hexadecenoate | C18H36O2 | 283.26 | ↑ | ↓ |
48 | Methylimidazole Acetaldehyde | C6H8N2O | 142.10 | ↓ | ↑ |
49 | L-Phenylalanine | C9H11NO2 | 164.07 | ↑ | ↓ |
50 | Sodium Formate | CHNaO2 | 90.98 | ↑ | ↓ |
51 | N-Acetylhistamine | C7H11N3O | 154.10 | ↓ | ↑ |
52 | Benzamidine | C7H8N2 | 138.10 | ↓ | ↑ |
53 | PE(0:0/18:2(9Z,12Z)) | C23H44NO7P | 476.28 | ↓ | ↑ |
54 | N-Acetyl-Alpha-D-Glucosamine 1-Phosphate | C8H16NO9P | 300.05 | ↑ | ↓ |
55 | 1-Pyrimidinylpiperazine | C8H12N4 | 165.11 | ↓ | ↑ |
56 | Dl-Propargylglycine | C5H7NO2 | 131.08 | ↓ | ↑ |
57 | N-(2,4-Dinitrophenyl)Ethylenediamine | C8H10N4O4 | 227.08 | ↑ | ↓ |
58 | (4-Aminophenyl)Phosphonic Acid | C6H8NO3P | 156.02 | ↑ | ↓ |
59 | (9z,11e,13z)-Octadeca-9,11,13-Trienoylcarnitine | C25H43NO4 | 422.33 | ↑ | ↓ |
60 | PE(18:0/0:0) | C23H48NO7P | 520.28 | ↑ | ↓ |
61 | 1,2-Diphenylhydrazine | C12H12N2 | 223.06 | ↑ | ↓ |
62 | L-Serine | C3H7NO3 | 106.05 | ↑ | ↓ |
