Fig. 6

Effect of VB17 and/or Sor on histopathology studies among the different groups: (A) Normal control group: Epicardial cell layer (arrowhead), cardiac blood vessel (asterisk), and branched cardiomyocytes (arrows). (B) EAC group: Shrinkage of cardiac muscle fibers (arrows), large area of necrosis (tailed arrow), and increased number of connective tissue fibers (arrowhead). (C) VB17 group: Normal cardiac muscle fibers (arrows) separated by connective tissue fibers (tailed arrow) and congestion of cardiac blood vessels (arrowheads). (D) Sor IP group: Normal cardiac muscle fibers (arrows) separated by connective tissue fibers (tailed arrow) and mild congestion of cardiac blood vessels (arrowheads). (E) SorO group: Normal cardiac muscle fibers (arrows), congestion of cardiac blood vessels with hemolysis (arrowheads), and mononuclear cell infiltrations (tailed arrow). (F) VB17 + SorIP group: Normal branched cardiac muscle fibers (arrows) with intact and regular-sized cardiac blood vessels (arrowhead). (G) VB17 + SorO group: Congestion and hemolysis inside cardiac blood vessels (arrowhead) in addition to mild vacuolar degeneration of cardiac muscles (arrow). (H) EAC + VB17 group: Shrinkage and mild degeneration in cardiac muscles (arrow) with dilation and congestion of cardiac blood vessels (arrowheads). (I) EAC + SorIP group: Severe congestion and hemolysis inside cardiac blood vessels with normal cardiac muscle architecture (arrows). (J) EAC + VB17 + SorIP group: Mild degeneration in cardiomyocytes (arrows) and increased connective tissue fibers (arrowheads). (K) EAC + SorO group: Severe hemorrhage (arrowheads) and necrosis of cardiac muscle fibers (arrow). (L) EAC + VB17 + SorO group: Degeneration (arrow) and shrinkage (tailed arrow) in cardiac muscle fibers with mild hemorrhage (arrowhead).