Fig. 4 | Scientific Reports

Fig. 4

From: Theabrownin combined with zearalenone suppresses colitis-associated colorectal cancer by inhibiting PI3K/AKT pathway and enhancing microbial propionate production

Fig. 4

TZ promoted apoptosis by regulating the PI3K/Akt signaling pathway. (A) Representative microscopic pictures of colonic sections under IHC staining in 400x magnification. Immunohistochemistry analysis H-score of (B) Ki67, and (C) c-casp3. (D) Representative immunoblots of p-PI3K/PI3K; p-Akt1/2/3/Akt1/2/3 and cyclin D1. Quantitative analysis of the relative expression of (E) p-PI3K/PI3K, (F) p-Akt1/2/3/Akt1/2/3, and (G) cyclin D1. Data are presented as mean ± SD (n = 6–10 per group). No “*” indicates p > 0.05; *p < 0.05; **p < 0.01; ***p < 0.001; ****p < 0.0001.

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