Fig. 3
From: Sex dependent effects of GPR109A gene deletion in myeloid cells on bone development in mice
µCT analysis of male tibia reveals early life improvements in trabecular bone for CKO mice compared to f/f and Cre+ controls. (A) µCT parameters for male tibia (f/f, Cre+ and CKO) at different time points (35 days, 3 months, 6 months, 12 months). BMD was significantly increased at 35 days for CKO mice compared to f/f and Cre+ controls. Yet at 12 months, Cre recombinase effect is observed as BV/TV, Tb N and BS/TV are significantly increased while Tb Sp is significantly decreased for both Cre+ and CKO mice compared to f/f controls. (B) Line graph of tibia BMD over all time points shows that early life BMD increase for CKO mice compared to other genotypes is not sustained throughout life. For One-way ANOVA, *P ≤ 0.05, **P ≤ 0.01, ***P ≤ 0.001, **** P ≤ 0.0001.
