Fig. 2 | Scientific Reports

Fig. 2

From: Lipidomic and transcriptomic profiling reveal alterations in the coexistence of gestational diabetes mellitus and preeclampsia impacting maternal and neonatal outcomes

Fig. 2

Lipidomics data analysis. (A) PCA plot of lipidomics data, colored by pregnancy complication groups: CTL (green), GDM (blue), PE (orange) and PG (red). (B) Pie chart showing the percentage distribution of major lipid categories based on the763 identified lipids. (C) Volcano plots displaying DELs between GDM, PE, and PG groups and the CTL group. Up-regulated lipids (FDR < 0.25 & log2(FC) > 0) are shown in red and down-regulated lipids (FDR < 0.25 & log2(FC) < 0) are shown in blue. (D) Bubble plots illustrating subclasses of DELs identified in (C). (E) Heatmap of scaled median lipid expression levels within each group, with an additional cutoff of |log2(FC)| > 1 to identify 43 DELs with higher confidence. Hierarchical clustering was performed using the ward.D2 method based on correlation distance.

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