Table 1 Ocular PK parameters after a single Eyedrop of 0.5% VIAN-c4551 to NZ rabbits.

From: Topical ophthalmic administration of the antiangiogenic peptide VIAN-c4551 protects against experimental diabetic macular edema

PK parameters

Retina-choroid

Vitreous

Cmax (ng g− 1 protein or ng mL− 1)

51,693.81 ± 6678.9

183.66 ± 15.49

Tmax (hours)

6

6

AUC0 − 24 h (hours × ng g− 1 protein or hours × ng mL− 1)

467,434 ± 45,884

1,678 ± 182

T1/2 (hours)

5 ± 0.78

4.7 ± 0.58

  1. Values are mean ± SEM. N = 3 eyes per timepoint. ng g− 1 protein is used for retina-choroid and ng mL− 1 for vitreous. AUC, area under the curve.
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