Table 1 Baseline characteristics of AMI population, across different liver indices (FIB-4, APRI and NFS scores).

From: Non-invasive scoring systems of liver fibrosis predict prognosis in the cohort with myocardial infarction

 

Overall for FIB-4 and APRIc

(N = 3287)

FIB-4 < 1.3

(N = 455)

1.3 ≤ FIB-4 < 3.25

(N = 1027)

FIB-4 ≥ 3.25

(N = 1805)

p-value

APRI ≤ 0.3

(N = 685)

0.3 < APRI < 1.5

(N = 1369)

APRI ≥ 1.5

(N = 1233)

p-value

Overall for NFSb, c

(N = 2143)

NFS < -1.455

(N = 161)

-1.455 ≤ NFS ≤ 0.676

(N = 684)

NFS > 0.676

(N = 1298)

p-value

Demographicsa

              

Age, year

64 (13)

58 (12)

65 (14)

66 (13)

p < 0.001

66 (13)

65 (14)

63 (13)

p < 0.001

67 (12)

58 (11)

65 (12)

69 (11)

p < 0.001

Female

797 (24.2)

117 (25.7)

289 (28.1)

391 (21.7)

p < 0.001

228 (33.3)

349 (25.5)

220 (17.8)

p < 0.001

545 (25.4)

27 (16.8)

157 (23.0)

361 (27.8)

p = 0.002

BMI (kg/m2) c

25.4 (4.7)

26.5 (4.9)

25.4 (4.6)

25.1 (4.7)

p < 0.001

25.8 (4.8)

25.4 (4.7)

25.1 (4.6)

p = 0.011

25.3 (4.71)

24.6 (4.2)

24.5 (3.9)

25.9 (5.1)

p < 0.001

Ethnicity

    

p = 0.006

   

p = 0.117

    

p = 0.485

Chinese

1799 (54.7)

211 (46.4)

565 (55.0)

1024 (56.7)

 

367 (53.6)

768 (56.1)

664 (53.9)

 

1270 (59.3)

99 (61.5)

399 (58.3)

772 (59.5)

 

Malay

710 (21.6)

119 (26.2)

221 (21.5)

370 (20.5)

 

175 (25.5)

278 (20.3)

257 (20.8)

 

491 (22.9)

38 (23.6)

166 (24.3)

287 (22.1)

 

Indian

547 (16.6)

90 (19.8)

168 (16.5)

288 (16.0)

 

100 (14.6)

233 (17.0)

214 (17.4)

 

290 (13.5)

17 (10.6)

87 (12.7)

186 (14.3)

 

Caucasian

14 (0.4)

0

5 (0.5)

9 (0.5)

 

4 (0.6)

4 (0.3)

6 (0.5)

 

7 (0.3)

0

4 (0.6)

3 (0.2)

 

Current smoker

961 (29.2)

143 (31.4)

253 (24.6)

565 (31.3)

p < 0.001

148 (21.6)

390 (28.5)

423 (34.3)

p < 0.001

564 (26.3)

62 (38.5)

199 (29.1)

303 (23.3)

p < 0.001

Past medical historya

              

Hypertension

2153 (65.5)

300 (65.9)

729 (71.0)

1124 (62.3)

p < 0.001

537 (78.4)

920 (67.2)

696 (56.4)

p < 0.001

1501 (70.0)

84 (52.2)

453 (66.2)

964 (74.3)

p < 0.001

Diabetes

1673 (50.9)

280 (61.5)

591 (57.5)

802 (44.4)

p < 0.001

445 (65.0)

701 (51.2)

527 (42.7)

p < 0.001

1182 (55.2)

46 (28.6)

302 (44.2)

834 (64.3)

p < 0.001

Hyperlipidaemia

2084 (63.4)

304 (66.8)

694 (67.6)

1086 (60.2)

p < 0.001

498 (72.7)

873 (63.8)

713 (57.8)

p < 0.001

1448 (67.6)

96 (59.6)

435 (63.6)

917 (70.6)

p < 0.001

Stroke

304 (9.2)

45 (9.9)

100 (9.7)

159 (8.8)

p = 0.628

82 (12.0)

127 (9.3)

95 (7.7)

p = 0.008

233 (10.9)

7 (4.3)

69 (10.1)

157 (12.1)

p = 0.009

Previous AMIc

900 (27.4)

124 (27.3)

374 (36.4)

402 (22.3)

p < 0.001

258 (37.7)

407 (29.7)

235 (19.1)

p < 0.001

651 (30.4)

31 (19.3)

210 (30.7)

410 (31.6)

p = 0.006

Chronic kidney disease

787 (23.9)

107 (23.5)

336 (32.7)

344 (19.1)

p < 0.001

253 (36.9)

336 (24.5)

198 (16.1)

p < 0.001

606 (28.3)

16 (9.9)

169 (24.7)

421 (32.4)

p < 0.001

  1. aCategorical variables are presented as n (%) and continuous variables are presented as mean (standard deviation). p < 0.05 is taken as statistical significance (in bold).
  2. bOut of a total of 3287 patients, 3287 (100%), 3287 (100%), and 2143 (65.2%) had the data necessary to calculate the FIB-4, APRI and NFS respectively.
  3. cAbbreviations: AMI, acute myocardial infarction; APRI, aspartate aminotransferase (AST) to Platelet Ratio Index; ARB, angiotensin receptor blockers; BMI, body mass index; FIB-4, Fibrosis-4 index; NFS, Non-alcoholic Fatty Liver Disease Fibrosis Score.
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