Fig. 1 | Scientific Reports

Fig. 1

From: The immune-related prognostic gene AIM2 promotes pancreatic cancer progression via inflammasome

Fig. 1

Construction and validation of immune-related genetic prognostic signatures. (A-B) LASSO Cox regression analysis was performed on 35 immune-related genes to refine the selection. (C) Displays the distribution of risk scores among patients. (D) Illustrates the survival status of patients based on the prognostic model. (E) Presents the expression levels of the genes in the TCGA-PAAD cohort. (F-H) Principal Component Analysis (PCA) of the expression distributions for: (F) The prognostic signature genes. (G) The entire immune-related gene set. (H) All genes in the gene expression profile, comparing high-risk and low-risk groups. (I) Univariate Cox proportional hazard regression analyses were conducted with risk Score and various clinicopathological features, including T, N, and M stages, pathological stage, smoking status, gender, and age. (J) Multivariate Cox proportional hazard regression analyses were also conducted with risk Score and the same set of clinicopathological features. (K) The prognostic value of the signature was assessed using the ROC curve analysis. (L) Kaplan-Meier survival analysis of pancreatic cancer patients from the TCGA, stratified by the median risk score.

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