Table 3 Mouse bioassay results for CWD-positive white-tailed deer maternal reproductive tissues. Cervidized (TgCerPrP−E2265037+/−) mice were intracranially (IC) inoculated with uterus (dams 6 − 1 and dam 7–10) and placentome (dams 6 − 1 fetus A and B, and dam 7–10 fetus A and B) samples. Terminal mouse brains were tested by conventional RT-QuIC for amyloid seeding activity. Mock inoculated mice remained free of clinical signs throughout, and tested CWD-negative upon terminal collections in all cohorts. DPI = days post inoculation. # pos/total mice = number CWD-positive/total number inoculated.
From: Vertical transmission of chronic wasting disease in free-ranging white-tailed deer populations
Location | Maternal tissue in bioassay | No. pos/total mice | DPI |
|---|---|---|---|
Tennessee | 6 − 1 Uterus | 6/6 | 256 ± 36.9 |
6–1 A Placentome | 4/4 | 256 ± 37.1 | |
6-1B Placentome | 5/5 | 263 ± 31.5 | |
West Virginia | 7–10 Uterus | 6/6 | 271 ± 22.3 |
7–10 A Placentome | 6/6 | 248 ± 20.9 | |
7-10B Placentome | 8/8 | 258 ± 25.9 | |
Negatives | 904 Uterus | 0/8 | |
904 Placentome | 0/8 | ||
