Fig. 5

(a) 2D projections of the principal eigenvectors (PC1 and PC2) of commercial compound estradiol benzoate run1 (Red), run2 (Yellow), and run3 (Orange) from the initial position till 200 ns MD simulations. (b) Principal component analysis (PCA) and free energy landscape (FEL) models of the commercial compound estradiol benzoate run1 (Red), run2 (Yellow), and run3 (Orange) from the initial position till 200 ns MD simulations.