Fig. 3 | Scientific Reports

Fig. 3

From: Tcf21 modulates fibroblast activation and promotes cardiac fibrosis after injury via Pdgfrb signaling

Fig. 3

Tcf21 bound to specific chromosomal regions related to extracellular matrix and PDGFRB. (a) DNA pulled down by chromatin immunoprecipitation (ChIP) was distributed around the transcription start site (TSS) and enhancer region. (b) Strong Tcf21 binding peaks were observed around the TSS of COL1A1, COL3A1, and IL6. (c) Result of motif analysis obtained using HOMER2 with a size parameter 200. Tcf21 majorly bound to the E-box domain (CAGCTG), and other DNA sequences, such as AP-1, TEAD4, and TWIST1 domains, were also detected as the Tcf21 binding motifs.

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