Fig. 4 | Scientific Reports

Fig. 4

From: In vivo anti-inflammatory evaluation of oxadiazole derivatives bearing flurbiprofen moiety using experimental and computational approaches

Fig. 4

In silico pharmacokinetic study of active oxadiazole derivatives (2, 3, 5, 7, 9, and 10) and flurbiprofen through SwissADME. (A) Bioavailability radar plot viewing the drug-likeness profile of each compound based on flexibility, saturation, solubility, polarity, size and lipophilicity. Compounds falling within the red zone are measured to have promising oral bioavailability. (B) BOILED-Egg model showing blood brain barrier penetration and gastrointestinal absorption potential. The plot also expects P-glycoprotein substrate status (PGP+ or PGP−), aiding in the assessment of pharmacokinetic distribution.

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