Table 1 14 independent genetic variants related to the type 2 dibaetes_prs (P < 5 × 10− 8).
From: Pathway insights and predictive modeling for type 2 diabetes using polygenic risk scores
rsID | Gene | Chr. | hg38 | Risk allele | OR (95% CI) | P value | INFO R2 |
|---|---|---|---|---|---|---|---|
rs1337028053 | -- | 5 | 106112143 | A | 2.97 (2.02–4.37) | 2.98E-08 | 0.7 |
rs9356744 | CDKAL1 | 6 | 20685255 | C | 1.13 (1.09–1.16) | 1.38E-14 | -- |
rs1431838560 | -- | 7 | 109778774 | C | 2.32 (1.74–3.10) | 1.25E-08 | 0.97 |
rs806214 | FSCN3 | 7 | 127596949 | A | 0.90 (0.87–0.93) | 1.20E-10 | 0.99 |
rs2233580 | PAX4 | 7 | 127613496 | T | 1.26 (1.21–1.32) | 1.67E-24 | -- |
rs201976370 | SND1 | 7 | 127969728 | A | 1.26 (1.20–1.32) | 1.54E-22 | 0.96 |
rs10811661 | CDKN2B-AS1;DMRTA1 | 9 | 22134095 | T | 0.88 (0.85–0.91) | 1.26E-16 | -- |
rs2283228 | KCNQ1 | 11 | 2828300 | A | 0.88 (0.85–0.91) | 1.19E-15 | -- |
rs2237895 | KCNQ1 | 11 | 2835964 | C | 1.18 (1.15–1.22) | 5.81E-28 | -- |
rs17676332 | TYRO3 | 15 | 41567301 | T | 1.32 (1.22–1.43) | 1.34E-12 | -- |
rs76072851 | CORO2B | 15 | 68640950 | T | 1.72 (1.62–1.82) | 8.31E-74 | -- |
rs527631646 | LINC01582;LINC02351 | 15 | 98177053 | C | 2.50 (1.82–3.43) | 1.73E-08 | 0.6 |
rs551262605 | PSMD3 | 17 | 39984855 | A | 3.13 (2.08–4.72) | 4.50E-08 | 0.72 |
rs148612115 | ZNF257 | 19 | 22089299 | T | 0.79 (0.74–0.85) | 1.92E-11 | 0.96 |
