Table 3 The canonical network analysis of PRS results in type 2 diabetes (P < 1 × 10− 5).
From: Pathway insights and predictive modeling for type 2 diabetes using polygenic risk scores
Ingenuity canonical pathways | -log(P value) | Molecules |
|---|---|---|
IL-15 Production | 3.51 | EPHA6,NTRK1,PEAK1,TYRO3 |
Thyroid Cancer Signaling | 2.93 | HNF1A, NTRK1,TCF7L2 |
Role of Osteoblasts in Rheumatoid Arthritis Signaling Pathway | 2.41 | CTSS, HNF1A, MMP3,TCF7L2 |
Sperm Motility | 2.33 | EPHA6,NTRK1,PEAK1,TYRO3 |
Aryl Hydrocarbon Receptor Signaling | 2.07 | MED1,NFIA, SMARCA4 |
HOTAIR Regulatory Pathway | 2.04 | HNF1A, MMP3,TCF7L2 |
WNT/β-catenin Signaling | 1.97 | HNF1A, TCF7L2,TLE4 |
Protein Citrullination | 1.88 | PADI1 |
Granulocyte Adhesion and Diapedesis | 1.87 | CSF3,EZR, MMP3 |
Basal Cell Carcinoma Signaling | 1.81 | HNF1A, TCF7L2 |
Pulmonary Healing Signaling Pathway | 1.81 | HNF1A, MMP3,TCF7L2 |
