Fig. 1
NSUN2 upregulation and RNA m5C hypermethylation in MM. (A) Expression of NSUN2 in patients with MM and healthy controls from GSE80608. (B) The relationship between the NSUN2 levels and ISS stages in GSE136400. (C) Relationship between NSUN2 expression and patient survival rate analyzed using Kaplan–Meier curves with dichotomized NSUN2 expression at the median. (D) Dot blot analysis displaying the RNA m5C hypermethylation pattern in three patients with MM and three healthy controls. (E) Expression of NSUN2 in bone marrow smears of normal control and MM patients examined by IHC. (F) NSUN2 mRNA expression in patients with MM and healthy controls detected by RT-qPCR. ***p < 0.001. MM, multiple myeloma; NSUN2, NOP2/Sun RNA methyltransferase family member 2; ISS, International Staging System; IHC, Immunohistochemistry; RT-qPCR, quantitative RT-PCR.
